Formononetin could increase soluble-APPα secretion by up-regulating ADAM10 level
نویسندگان
چکیده
منابع مشابه
Formononetin protects neurons against hypoxia-induced cytotoxicity through upregulation of ADAM10 and sAβPPα.
Formononetin, an active constituent of the Chinese herb Astragali Radix, has been reported to have beneficial effects for Alzheimer's disease (AD). Yet the mechanism of this effect remains to be elucidated. The present study shows that formononetin increases soluble-AβPPα (sAβPPα) secretion and thus protects human-AβPP Swedish mutation cell (N2a-AβPP cell) from hypoxia-induced apoptosis. Using ...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2012
ISSN: 1750-1326
DOI: 10.1186/1750-1326-7-s1-o10